1. We do not know that it "only" originated once. There are still bacteria around that clearly originated when there was no free oxygen on Earth. However, that is rare, bringing us to:
2. There is a dominant life-form that took control of the environment. When plants took control and transformed Earth's atmosphere by dumping all this oxygen "pollution", that pretty well settled it for any newer form of life. It became very difficult to create conditions that would make it probable to assemble (different types of) long molecules with the ability to reproduce themselves.
3. By the time the "original" lifeforms had taken over, many chains of molecules had been pre-arranged (enzymes, proteins...). This greatly favored the formation of available atoms into molecules that had magnetic signatures (weak bonds) compatible with existing molecules. That would make it very difficult to find sufficient "free" atoms to assemble in types of molecules that would be substantially different than the ones that had taken over.
4. Once a different life form exists (if it ever does), it has to "feed". If most of the existing molecules that can provide chemical energy are already assembled with a magnetic signature compatible with the existing dominant lifeform, they might not be available as "food" for the newer lifeform.
A bit similar to the question sometimes asked in s-f stories: if we land on another planet and we see plants, will it be food for us, poison, or simply inert (i.e., we would be unable to assimilate and digest it). Even on this planet, there are plants on which other animals can feed, but that would provide humans with no nutritional value at all (e.g., wood).